产品货号：
Z21093
中文名称：
Mouse MER/MERTK抗体
英文名称：
Anti-Mouse MER/MERTK Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Mouse MER/MERTK Antibody (C-term) |
| 指标别名 | Tyrosine-protein kinase Mer;Proto-oncogene c-Mer;Receptor tyrosine kinase MerTK;Mertk;Mer |
| 克隆性 | Polyclonal |
| 检验物种 | mouse,rat |
| 应用范围 | WB |
| 基因名称 | Mertk |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This Mouse Mertk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 946-980 amino acids from the C-terminal region of mouse Mertk. |
| 计算分子量 | 110kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3,TUB,TULP1 or GAS6.Regulates many physiological processes including cell survival,migration,differentiation,and phagocytosis of apoptotic cells (efferocytosis).Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules.Following activation by ligand,interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1,MAPK2,FAK/PTK2 or RAC1.MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells,platelet aggregation,cytoskeleton reorganization and engulfment.Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis.Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1,which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
| Uniprot ID | Q60805 |
相关搜索：Mouse MER/MERTK抗体，Mouse MER抗体，MERTK(C-term)多抗，Anti-Mouse MER/MERTK Antibody (C-term)